Cannabinoids are chemical compounds found in cannabis, which account for the therapeutic advantages linked to medical marijuana. Each cannabinoid has its own set of traits that may be beneficial in a variety of illnesses. To fully comprehend how medical marijuana might assist, researchers must examine as many cannabinoids as feasible. Cannabigerol (CBG) is a less popular cannabinoid that isn’t abundant in most strains and can’t be found in high amounts. Despite this, it’s important to understand what makes it so special.
What You Need to Know About Cannabigerol (CBG)
Hemp has a chemical in it called cannabigerol (CBG), which is non-psychoactive and inhibits the psychoactive effect and metabolic response to THC. CBG actually inhibits the psychotropic reaction as well as the metabolic response caused by THC. CBG also fights insomnia, destroys cancer cells, is antibacterial, and promotes neurogenesis.
Despite this, there have been no complete studies conducted on CBG at this point in time, and hemp strains never contain a large amount of it. It appears that cannabigerol is present in hemp strains at a concentration of around 0.2 to 2 percent. Every variety of medicinal marijuana has a trace amount of cannabigerol, which might be anywhere from 0.1 to 1 percent.
The most euphoric psychotropic cannabinoid in Cannabis, THC is less harmful than some of its relatives. CBG, on the other hand, is found in greater quantities in cannabis plants containing more THC. Cannabis growers interested in producing a high-CBG strain could utilize cannabis plants aged 6 weeks or older for testing and potentially develop cannabigerol-rich marijuana strains.
CBG, like the other cannabinoids, has a wide range of applications that can benefit people all around the world who suffer from various health issues. It is particularly helpful in treating diseases affecting the central nervous system. Here are some examples:
- Chronic pain
- Skin disease
- Neurological illnesses
The psychoactive effect of THC is one of the most significant reasons why the government has sought to limit cannabis use and distribution. Fortunately, the effort to further study marijuana’s health advantages has produced data that makes their attempts to prohibit marijuana seem misguided.
How Does CBG Function?
CBG does not cause intoxication comparable to THC, but it can successfully inhibit the reaction you have to THC. Because it promotes harmony, it could also help other cannabinoids do the same. CBG acts as an agonist for cannabinoid receptors such as CB1 and CB2, much like all cannabinoids. Unlike its counterpart THC, cannabigerol has a lesser effect on receptors because of this.[
CBG may promote the amount of anandamide in the body, which is a cannabinoid that is naturally present. CBG has been shown to have several biological functions, including sleep, hunger, and memory.
Anandamide, like THC, works through CB1 and CB2 receptors. Cannabigerol inhibits the activity of gamma-aminobutyric acid (GABA). GABA is a brain chemical that controls nerve function.
Cannabigerol has a greater impact on GABA usage than THC or CBD. CBG effectively balances the fight or flight response in the body. Its function in maintaining certain receptors suggests that it might have several uses below.
- Slows down noradrenaline release
- Manages fight or flight
- Reduces vascular smooth muscle
- Mimics the reduction of high blood pressure
- Lessens smooth muscle mobility in the gastrointestinal tract
- Offers analgesia effects
- Stops the disintegration of lipids into fatty acids
Cannabigerol clearly has the potential to be a highly beneficial medication in the treatment of a variety of medical problems. The fact that it can also help relieve symptoms of depression by affecting the central nervous system without producing intoxication makes it even more appealing to scientists and patients worldwide.
How is cannabigerol made?
CBG is a minor cannabinoid since it is present in very small amounts (usually less than 1 percent) in the majority of cannabis strains. Cannabigerolic acid (CBGA), the precursor to the three primary cannabinoid lines: tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), and cannabichromenic acid (CBCA), is formed by cannabis plants.
CBGA is broken down by enzymes in the plant, and it “directs” itself toward one of the three lines. The acids are exposed to UV light or heat, and there you have it: they’re transformed into THC and CBD. In most strains, CBGA is converted to either THCA or CBDA as soon as possible. As a result of how these chemicals are produced, more THC always means less CBG and CBD (and vice versa).
White CBG, Super Glue CBG, and Jack Frost CBG are just a few of the strains that have more CBG than other cannabis varieties. These strains are developed to create larger amounts of CBG.
CBD and THC are created in the same way as CBGA, an acidic version of CBG. This is why younger cannabis plants have higher levels of CBG. Because the plant has grown larger, most of the CBG has been changed to CBD and THC as it developed.
Breeders are attempting out various techniques, such as genetic manipulation and cross-breeding, to improve CBG yields. For example, Subcool Seeds is crossing strains in order to achieve higher CBG levels. Scientists can also increase the amount of CBG in developing plants by determining the optimal extraction time, which is around six weeks into an eight week flowering cycle for Bediol, a medicinal strain developed by the Dutch firm Bedrocan BV Medicinal Cannabis.
Benefits and Effect of CBG
CBG has shown to reduce pain in some studies. However, certain research suggests that it is more effective than CBD in treating neuropathic pain. It was found to be an excellent antidepressant in additional research. According of scientific study, the following are some of CBG’s medical applications:
- Inflammatory bowel conditions
- Crohn’s disease
Despite the fact that studies have concentrated on CBG’s effects in animals, it is still intriguing because of its potential impact on human health. So far, research has shown that cannabigerol may improve your general health by destroying bacteria, preserving neurons, inhibiting cancer cell formation, and increasing appetite. It aids with bladder problems and inflammation while also lowering eye strain and relieving discomfort in the bladder.
Cannabinoid receptors are proteins located on the cell membrane that bind cannabinoid compounds. Cannabinoid receptors are classified as CB1 and CB2, with CB1 receptors being found in the brain and nervous system and CB2 receptors being present in the immune system and other parts of the body.
CBG activates CB1 and CB2 receptors, which are known to improve the activity of anandamide, a neurotransmitter that promotes pleasure and motivation, controls appetite and sleep, reduces pain. Unlike THC, CBG has no psychoactive effects; as a result, it will not make you high.
How to Use CBG
CBG is usually produced as an oil for consumers. Pure CBG oil can help you obtain the advantages of CBG. CBG oils, on the other hand, are rare and costly. The good news is that broad-spectrum CBD oils might provide some of CBG’s benefits. Broad-spectrum CBD oils include all of the cannabinoids present in a cannabis plant, including CBG, but not THC.
CBG has a long list of advantages for internal usage, but it also has some benefits when used topically. It protects against oxidative stress and inflammation, and when applied transdermally, it has been shown to reduce both inflammation and pain. However, what it’s made of matters: CBG is more effectively absorbed into the skin when used with certain product thickeners. As a result, knowing the amount of CBG in a skincare or beauty product isn’t sufficient; brands must also be transparent about how they create it. Terra/form’s Tariq is particularly proud of this last point; his company customizes each component ratio in every product to maximize CBD and CBG absorption, which he claims “is our magic formula.”
Tariq places the difference between CBG and CBG use in skin care and body care. “We start with naturally occurring levels of Cannabinoids in our skincare range, but for our body care wellness items, we use high amounts of CBD-CBG to get the synergistic benefits for calmer, healthier, and younger skin,” he explained.
When cannabinoids are utilized in combination, the entourage effect occurs, which improves their efficacy.
CBG’s potential medical benefits
The human body’s built-in endocannabinoid system (ECS) works to maintain the body in its normal condition of equilibrium. While there are specific elements about how cannabinoids function, the endocannabinoid system as a whole performs many functions that are particular to various portions of the body. The ECS, for example, may help control immune cells at a site of injury to limit inflammation.
CBD appears to have a variety of health benefits, including anti-depressant effects and activity against brain disorders, particularly in children. CBD has been found to work on a number of physiological systems and ailments, with promising outcomes for medical usage:
- Endocannabinoid receptors are present in the eyes, and CBG is thought to be particularly useful in glaucoma therapy since it lowers eye pressure. It’s a strong vasodilator with neuroprotective qualities.
- CBG was discovered in animal trials to be helpful in decreasing inflammation caused by inflammatory bowel diseases in mice.
- CBG was discovered to protect neurons in mice with Huntington’s disease, which is characterized by nerve cell degeneration in the brain, in a 2015 research.
- Cannabigerol (CBG) has shown promise as a cancer therapy. CBG was found to block receptors that promote cancer cell growth in one study. Colon cancer cells were inhibited in mice, suggesting that CBG might slow the development of colon tumors. CBG blocked tumor growth and chemically induced colon carcinogenesis, indicating that it may be useful in the treatment of colorectal cancer.
- CBG has been found in several studies to be an antibacterial substance, especially against methicillin-resistant Staphylococcus aureus (MRSA) bacteria strains that are resistant to many types of medications. Since the 1950s, topical treatments containing cannabis have shown promise in skin disorders, but scientists at the time were unaware of the plant’s chemical makeup.
- In a recent 2017 research, researchers demonstrated that CBG purified to remove delta-9 THC is a highly effective appetite stimulant in rats. This may lead to the development of a non-psychoactive therapeutic option for cachexia, which is when muscles begin to waste away and people lose weight.
- In a research that evaluated the effects of five different cannabinoids on bladder contractions, CBG proved to be most effective at blocking muscular contractions, implying it may be a future approach to prevent bladder issues.
Where to Find Strains with High Levels of CBG
Now that you’ve seen the advantages of CBG, the main issue is determining how to obtain it. Fortunately, some producers are focusing on increasing cannabis production with more CBG content. The problem is that cannabis growers tend to combine THC and terpenes since they believe cannabinoids and terpenes work better when combined to achieve greater effects.
Yes, it’s difficult to locate CBG-rich strains, but there are a few options:
- Williams Wonder
It’s a CBG-rich marijuana strain that’s been known to have about 30% cannabigerol in it. This version does contain 20% THC, so you may be unaware of the CBG content. The most essential aspect is that you will still receive the advantages of this strain, such as nausea relief, pain alleviation, depression and anxiety management.
- Exodus Cheese
CBG, a chemical in the plant CBGA, is an excellent cannabinoid that can help you sleep better and feel more energetic. This strain is ideal for individuals who are new to high CBG strains. It’s especially useful if you want fewer THC than other strains but more of the direct effects of CBG. By inhalation, you’ll get there faster.
Destroyer is a Sativa-dominant hybrid strain with Mexican, Thai, and Columbian ancestry. It’s a 100% Sativa plant that has its own identity. It’s only 10-15% THC and is ideal for cannabis enthusiasts who have tried it before. You won’t get high since the psychoactive effects are mild enough that you can concentrate clearly while smoking it.
CBG is a very rare cannabinoid because of the difficulties in producing it. It’s far more difficult to make than other cannabinoids such as THC and CBD. Manufacturers would rather produce CBD since CBG has many similarities with CBD.
CBG is a difficult substance to manufacture. However, as CBG is produced, its end products become increasingly costly. CBG has a lot of appealing advantages and new study is being conducted into making the cannabinoid easier to produce and distribute.
CBD is not the newest CBD. CBG, on the other hand, isn’t exactly a new CBD. Because it’s a parent cannabinoid and CBG was formerly CBG during plant development, prior to conversion, it is technically considered the old CBD. Although the advantages of CBG outweigh those of CBD, CBD can be used alone because to its benefits; however ,CBG works best when combined with CBD. Knowing how they relate to each other is important for getting the most out of them, and there are plenty of reasons why you should try CBG (better mood, better skin).